What is MOTS-c?

MOTS-c, short for Mitochondrial-derived Peptide (Mitochondrial Open Reading Frame of the 12S rRNA-type-c), is a small peptide encoded by the mitochondrial genome. It was discovered relatively recently and is gaining attention for its potential role in metabolic regulation and age-related processes.
MOTS-c is believed to be involved in various cellular processes, including energy metabolism, insulin sensitivity, glucose regulation, and mitochondrial function. Research suggests that MOTS-c may act as a signaling molecule, communicating between the mitochondria and the nucleus to regulate gene expression and metabolic pathways.

How does MOTS-c work?

MOTS-c, or Mitochondrial-derived Peptide (Mitochondrial Open Reading Frame of the 12S rRNA-type-c), is a small peptide encoded by the mitochondrial genome. Although the precise mechanisms of MOTS-c are still being elucidated, research suggests that it exerts its effects through several pathways:

1. Metabolic Regulation: MOTS-c appears to play a role in metabolic regulation by influencing cellular energy metabolism. It interacts with key metabolic pathways, including glucose and lipid metabolism, to help regulate energy production and utilization within cells.

2. Mitochondrial Function: MOTS-c is believed to target mitochondria, the cellular organelles responsible for energy production. It may help improve mitochondrial function by enhancing oxidative phosphorylation, the process by which mitochondria generate ATP, the cell’s primary energy source.

3. Gene Expression: MOTS-c has been shown to modulate gene expression by interacting with nuclear DNA. It may act as a signaling molecule, communicating between the mitochondria and the nucleus to regulate the expression of genes involved in metabolism, stress response, and cell survival.

4. Insulin Sensitivity: Studies have suggested that MOTS-c can improve insulin sensitivity and glucose uptake in cells. By enhancing insulin signaling pathways, MOTS-c may help regulate blood sugar levels and prevent insulin resistance, a hallmark of metabolic disorders like diabetes.

5. Anti-Aging Effects: MOTS-c has been implicated in the regulation of aging processes. It may help maintain cellular homeostasis and protect against age-related decline in mitochondrial function and metabolic health. By promoting cellular health and resilience, MOTS-c may contribute to healthy aging and longevity.

Overall, MOTS-c appears to play a multifaceted role in cellular metabolism, energy regulation, and aging processes. Further research is needed to fully understand its mechanisms of action and therapeutic potential in various health conditions.

What you need to know:

When cells are damaged, they sense their damage, and they can pause. This process is called cellular senescence or cellular arrest. Cells are programmed to do this because they don’t want to replicate with damage.

Instead, they pause until the immune system can clear them. Until cleared, senescent cells secrete signals that cause harm to the body. These signals increase inflammation, exhaust stem cells, and cause the body to age more rapidly. While senescence is natural, clearing senescent cells is vital to stop the aging process.

Dose: 5 mg/vial
Dosing Guideline: 10mg once/week