What is ARA-290?

ARA-290 is an 11-amino acid linear peptide and a synthetic peptide designed to mimic the effects of erythropoietin (EPO), a hormone produced naturally in the body that regulates red blood cell production. However, unlike EPO, ARA-290 does not stimulate erythropoiesis (red blood cell production) or affect hematopoiesis (blood cell formation). Instead, ARA-290 exerts its therapeutic effects through modulation of the innate repair receptor (IRR).

The innate repair receptor (IRR) is a receptor found on the surface of cells that plays a key role in tissue repair and regeneration. Activation of the IRR triggers a signaling cascade that promotes tissue healing, reduces inflammation, and protects cells from damage.

Experimental data suggest that after peripheral nerve injury, the IRR is unregulated in the spinal cord and modulates the neurogenic inflammatory response.

How does ARA-290 work?

ARA-290 works by selectively activating the IRR without affecting other erythropoietin receptors or erythropoiesis. When ARA-290 binds to the IRR, it initiates a series of cellular responses that contribute to tissue repair and regeneration. These responses include:

1. Anti-inflammatory effects: ARA-290 helps reduce inflammation by inhibiting the production of pro-inflammatory cytokines and promoting the release of anti-inflammatory mediators. By dampening the inflammatory response, ARA-290 helps limit tissue damage and promote healing.

2. Promotion of tissue repair: ARA-290 enhances the migration, proliferation, and survival of cells involved in tissue repair, such as endothelial cells, fibroblasts, and stem cells. By stimulating these cellular processes, ARA-290 accelerates the repair of damaged tissues and promotes tissue regeneration.

3. Protection against apoptosis: ARA-290 protects cells from apoptosis (programmed cell death) induced by various stressors, such as oxidative stress, inflammation, and injury. By preventing cell death, ARA-290 helps preserve tissue integrity and function.

4. Neuroprotective effects: ARA-290 has shown neuroprotective properties in preclinical studies, suggesting its potential for treating neurodegenerative disorders and neurological injuries (Neuropathic pain). ARA-290 promotes neuronal survival, reduces neuroinflammation, and enhances neural repair mechanisms.

What is Neuropathic pain? What are the causes?

Neuropathic pain is observed in a large variety of disorders that vary from metabolic and infectious disorders, which affect the small, afferent sensory nerve fivers such as sarcoidosis to diseases of the central nervous system like multiple sclerosis.

Targeting the innate repaid receptor to treat neuropathy:

In this study, ARA-290 displayed efficacy in preclinical models of disease, including neuropathy, without associated adverse effects. In the models from this study, this peptide has been shown to reprogram a proinflammatory, tissue-damaging milieu into one of healing and repair.

Indications of ARA-290:

• Reduce pains

Dose: 20 mg/vial
Dosing Guideline: 5 mg/4times/week