Tesamorelin
What is Tesamorelin?
Mechano-growth factor (MGF) is an anabolic peptide found in muscle, bone, tendon, neural, and cardiac tissue following periods of increased stress. It is a split variant or isoform of insulin-like growth factor-1 (IGF-1), also known as IGF-1Ec. MGF functions to increase stem cell proliferation in given tissues, allowing for more rapid recovery.
How does Tesamorelin work?
The hypothalamus releases GHRH and stimulates the pituitary glands production of Growth Hormone (GH). As an analog of GHRH, Tesamorelin with “Trehalose” is able to stimulate the production of GH by the same mechanism. GH goes on to stimulate IGF-1 production in the liver. The resulting increased levels of GH and IGF-1 in the blood results in a variety of beneficial growth effects in tissues.
When Tesamorelin is administered, it binds to specific receptors on the surface of pituitary cells, activating them to produce and release GH. This leads to an increase in circulating levels of GH, which in turn stimulates the liver and other tissues to produce insulin-like growth factor 1 (IGF-1), a hormone with various metabolic effects.
Indications of Tesamorelin:
- Improve cognition in people over 60 years of age
- Increase IGF-1
- Increase Muscle
- Reduce carotid intima media size (cIMT)
- Reduce visceral adipose tissue (VAT)
- Reduce triglycerides
The primary effect of Tesamorelin is the reduction of excess visceral adipose tissue (VAT), particularly in the abdomen, in individuals with HIV-associated lipodystrophy. It achieves this by promoting lipolysis, the breakdown of fat cells, and inhibiting lipogenesis, the formation of new fat cells. This results in improvements in body composition and metabolic parameters, helping to reduce the risk of metabolic complications associated with excess abdominal fat accumulation.
What you need to know:
Tesamorelin should not be used while pregnant or breastfeeding. Always tell your physician about all medications and supplements, especially corticosteroids and thyroid medications, that you are taking. Common side effects of Tesamorelin include reactions at the injection site, such as pain, redness or swelling. Some Patient might experience joint pain, pain in legs and arms, swelling in your legs and muscle pain.
Dose: 10 mg/vial
Dosing Guideline: 1 mg for 5 or 7 days/week