What is PT-141 (Bremelanotide)?

Bremelanotide PT-141 was developed from the peptide hormone Melanotan II for aphrodisiac effects. Bremelanotide PT-141 effects sexual function via interaction with the hypothalamus. Its usage has been found to induce rapid onset of arousal. Found to increase erection in 80% of males who did not respond to Viagra or Cialis. Bremelanotide PT-141 has shown to increase chances of women achieving at least one sexually gratifying experience by 50%.

What forms of Bremelanotide PT-141 are available?

Bremelanotide PT-141 is available for subcutaneous injection and intranasal spray.

How does Bremelanotide work?

Bremelanotide, also known as PT-141, works by activating melanocortin receptors in the brain, specifically the melanocortin 4 receptor (MC4R). Here’s a detailed look at its mechanism of action:

1. Receptor Activation: Bremelanotide binds to melanocortin receptors, particularly MC4R, which are involved in the regulation of sexual arousal and desire. These receptors are part of the central nervous system and play a role in various physiological functions, including appetite, energy homeostasis, and sexual behavior.

2. Neural Pathways: By stimulating these receptors, Bremelanotide influences neural pathways that control sexual arousal. This leads to an increase in the release of neurotransmitters such as dopamine, which is associated with the reward and pleasure centers of the brain.

3. Increased Blood Flow: In men, this activation can enhance blood flow to the genital area, aiding in the attainment and maintenance of an erection. However, unlike other treatments for erectile dysfunction, such as phosphodiesterase type 5 inhibitors (e.g., sildenafil or tadalafil), Bremelanotide does not work directly on the vascular system but rather acts centrally to increase sexual desire and arousal.

4. Sexual Desire: For women, Bremelanotide has been shown to improve sexual desire and decrease distress related to low sexual desire, making

Why would I want to use PT-141(Bremelanotide)?

• Produce rapid onset of sexual arousal
• Heighten libido
• Improve symptoms of female sexual dysfunction
• Induce erection in men suffering from ED
• Improve sexual dysfunction on the level of central nervous system

What you need to know: –

Reported side effects of Bremelanotide PT-141 are flushing, nausea and gastrointestinal upset No contraindications have been reported.

Dose: 10 mg/vial

Dosing Guideline: 1-2 mg (0.1-0.2 ml or 10-20 units) SC up to 3 times/week or 1-2 hours prior to desired effect